US Close 24 September 2026: S&P 500 Flat at 7,704 as a Genomics Surge Offsets a 5.16% 10-Year Yield
The S&P 500 closed at 7,704.13 on 24 September 2026, down 1.90 points or 0.02%, as a 5.13% gain in the ARK Genomic Revolution ETF (ARKG.US) cancelled the drag from a 10-year Treasury yield that reached 5.18% intraday, its highest since 2007. TWST.US topped every name on the $2 billion-plus screen at +16.11% to $184.03, extending the run that began with its antibody-characterisation supply agreement into Eli Lilly's TuneLab drug-discovery platform. Brent crude settled the session at US$107.03, up 3.83%, after Houthi missile fire at Saudi Arabia lifted it to a US$108.23 high and a Reuters report of phased Strait of Hormuz reopening talks pulled it back.
At a glance
| Index | Close | Change |
|---|---|---|
| S&P 500 | 7,704.13 | -0.02% |
| Nasdaq Composite | 26,939.37 | +0.01% |
| Dow Jones Industrial Average | 51,349.98 | -0.31% |
| Russell 2000 | 2,835.57 | -0.11% |
| VIX | 15.67 | +3.23% |
US 10-year yield 5.162%, up 4.8 bp. US 30-year yield 5.461%, up 6.0 bp and a 22-year high. US Dollar Index 101.27, up 0.17%.
What moved the index
The S&P 500 finished 24 September 2026 within 2 points of its prior close because two sectors added roughly 20 bps and three took back about 22 bps.
| Driver | Sector move | Index contribution |
|---|---|---|
| Communication services (XLC.US) | +1.27% | about +14 bps |
| Healthcare (XLV.US) | +0.63% | about +6 bps |
| Technology (XLK.US) | -0.32% | about -11 bps |
| Industrials (XLI.US) | -0.75% | about -6 bps |
| Consumer staples (XLP.US) | -0.89% | about -5 bps |
Sequencing and diagnostics supplied healthcare's contribution. ILMN.US added 7.25% to $273.90, NTRA.US 4.61% to $408.79, CRL.US 6.17% to $294.44. Technology's drag concentrated in two names: ARM.US fell 7.88% to $306.34 and SNX.US 9.87% to $259.47.
Session highlights
Genomics and life-science tools took five of the ten largest gains above $2 billion in market value on 24 September 2026.
- TWST.US +16.11% to $184.03 on the antibody-data supply agreement into Eli Lilly's TuneLab platform and a Leerink Outperform reiteration.
- GRAL.US +15.38% to $125.21, CDNA.US +13.00% to $61.37 and VCYT.US +10.77% to $48.54 tracked the same multi-cancer-screening and transplant-diagnostics bid; ARKG.US closed +5.13% and XBI.US +0.55%.
- 11.23% was TXG.US to $84.11, with the instrument makers behind it: BRKR.US +7.26% to $64.00, ICLR.US +6.10% to $173.90, RVTY.US +6.03% to $150.68.
- P.US +11.15% to $121.88 after S&P 500 inclusion effective 21 September and a preliminary FY2028 revenue outlook of $7.0 billion to $7.3 billion, 39% to 45% above the FY2027 guide of $5.03 billion to $5.07 billion.
- ARM.US -7.88% to $306.34 as ISS and Glass Lewis urged shareholders to vote against an $800 million executive bonus plan; SFTBY.US -7.16% to $19.57.
- DRI.US -3.02% to $207.24 on Q1 FY2027 diluted EPS of $2.05 and blended same-restaurant sales of +3.1%, with Olive Garden at +1.1% against LongHorn at +6.2%.
Sector scorecard
Eight of the eleven S&P 500 sectors fell on 24 September 2026, with materials the weakest at -1.19%.
- XLC.US +1.27%, XLV.US +0.63% and XLE.US +0.37% were the only three sectors to close higher.
- XLB.US -1.19%, XLU.US -0.98% and XLP.US -0.89% led the decliners, KGC.US -11.59% the single largest materials drag.
- XLK.US -0.32% and XLF.US -0.02% held near flat despite the 5.162% 10-year close.
Top movers
| Gainer | Change | Close |
|---|---|---|
| TWST.US | +16.11% | $184.03 |
| GRAL.US | +15.38% | $125.21 |
| SECZ.US | +15.11% | $16.53 |
| CDNA.US | +13.00% | $61.37 |
| WRBY.US | +12.51% | $26.27 |
| Loser | Change | Close |
|---|---|---|
| ACAD.US | -12.78% | $22.18 |
| GEN.US | -12.05% | $23.07 |
| GIL.US | -12.04% | $40.63 |
| VKTX.US | -11.76% | $36.75 |
| KGC.US | -11.59% | $24.42 |
- ACAD.US -12.78% to $22.18 after remlifanserin missed the primary SAPS H+D endpoint while clearing the key secondary CGI-S-ADP measure.
- KGC.US -11.59% to $24.42 on a cut to 2026 and 2027 attributable output, now 1.84m to 1.86m gold-equivalent ounces or 2% to 3% under the prior low end, with 2026 all-in sustaining cost guidance raised to $1,850 to $1,900 an ounce from $1,730 after severe winter weather at La Coipa and lower grades at Round Mountain.
- VKTX.US -11.76% to $36.75 on a $225 million common-stock offering priced at $35.00, the low end of the $35.00 to $38.00 range and raised from $200 million.
- MGM.US -10.99% to $33.69 after People Inc. withdrew its proposal for all MGM public shares while keeping 66.8 million shares, about 27% of the company.
- WRBY.US +12.51% to $26.27, with a Loop Capital 2026 best-ideas addition the named catalyst.
- SECZ.US +15.11% to $16.53. Unannounced, likely flow-driven.
- GIL.US -12.04% to $40.63 and FSLR.US -10.32% to $172.16, a 52-week low. No fresh announcement on either; the HanesBrands integration and a low-end 2026 revenue range remain Gildan's stated overhang.
After-hours earnings
COST.US reported fiscal Q4 2026 after the 16:00 ET close on 24 September 2026 with net sales up 11.2% to $93.9 billion and diluted EPS of $6.75 against a $6.48 consensus of 11 analysts surveyed by Zacks.
- COST.US closed the regular session at $896.48, down 0.91%, then traded about 1% higher immediately after the release.
- $9.226 billion full-year net income, or $20.76 per diluted share, against $8.099 billion and $18.21 a year earlier.
- $0.15 per diluted share of the quarter came from non-recurring IEEPA tariff refunds, partly reinvested in member value.
Next session catalysts (ET)
- 5.162% on the 10-year and 5.461% on the 30-year are the levels Friday's open prices against, the first a 2007 high and the second a 22-year high.
- US$107.03 Brent and US$94.76 WTI hold the energy input; the reported US and Iran talks on a phased Strait of Hormuz reopening are the swing factor.
- COST.US earnings-call commentary carries into Friday after the roughly 1% post-release move.
- 15.67 on the VIX, up 3.23%, is the volatility reading going in.
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